A research team from the University of Hawaii may have identified how asbestos exposure causes mesothelioma.
Dr Haining Yang and Michele Carbone led the team that included researchers from around the world.
The team found that when asbestos fibres kill cells they start a process called “programmed cell necrosis”. This causes the cell to release a protein, HMGB1. The protein leads to changes in a cell’s genetic structure that cause it to mutate into a malignant cancer cell.
The researchers found people exposed to asbestos have higher levels of the protein in their serum, which may allow earlier identification and treatment of the disease.
The team is now planning to start clinical trials in a remote region in Cappadocia, Turkey, where more than half of the population dies from mesothelioma.
These findings open up a range of research possibilities that could help to find new treatments for mesothelioma. We hope that the clinical trials in Turkey produce positive results that can then be applied elsewhere to help those suffering from this dreadful disease.